San Francisco Vacation Packages

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Your San Francisco Vacation

When a fun city break is calling, answer it with a vacation package to San Francisco. The neighborhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco vacation is just a few clicks away. Explore flights, accommodations and more on Expedia for an adventure that's tailored to suit your travel style.

Top Holiday Package Deals in San Francisco

Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was CA $3,455, price is now CA $1,853 per person
CA $1,853
per person
Dec 17 - Dec 23
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.6/10 Excellent! (1,803 reviews)
Shops nearby

Reviewed on Nov 6, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was CA $3,953, price is now CA $2,106 per person
CA $2,106
per person
Dec 23 - Dec 27
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.2/10 Wonderful! (1,015 reviews)
In the heart of Casco Viejo, the first hotel built but you could not tell as it has been remodeled. A lot of history. The place is beautiful and well maintained. We went on a sailing trip for 2 days and the held our bags at no extra cost. The staff is great and the restaurant in the back is absolutely delicious! Lots of great restaurants around as well. There is a Speakeasy nearby called Villa Ana 1928, second floor above the restaurant, don’t miss it!

Reviewed on Nov 5, 2026

La Concordia Boutique Hotel

La Concordia Boutique Hotel

4 out of 5
Casco Viejo
Price was CA $4,364, price is now CA $2,882 per person
CA $2,882
per person
Jan 7 - Jan 14
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
9.6/10 Exceptional! (244 reviews)
Had a very nice day and a beautiful room. Would definitely stay there again.

Reviewed on Oct 19, 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

3.5 out of 5
Casco Viejo
Save 100% on your flight
Price was CA $12,211, price is now CA $8,111 per person
CA $8,111
per person
Dec 28 - Jan 4
found 1 day ago
Roundtrip non-stop flight included
Montreal (YMQ) to Panama City (PTY)
9.8/10 Exceptional! (30 reviews)
I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect. The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us. I would stay here again in a heart beat. It’s a must stay!

Reviewed on Sep 16, 2026

Casa Lefevre By Wynwood House

Casa Lefevre By Wynwood House

3 out of 5
Casco Viejo
Price was CA $3,657, price is now CA $2,539 per person
CA $2,539
per person
Jan 7 - Jan 14
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
9.6/10 Exceptional! (16 reviews)

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

San Francisco Hotel Deals

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $133 per night from Nov 16 to Nov 17
CA $133
CA $147 total
Nov 16 - Nov 17
includes taxes & fees
Ramada Plaza by Wyndham Panama Punta Pacifica
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
The price is CA $184 per night from Nov 11 to Nov 12
CA $184
CA $203 total
Nov 11 - Nov 12
includes taxes & fees
8.6/10 Excellent! (1,840 reviews)
"Shops nearby"

Reviewed on Nov 6, 2026

Megapolis Hotel Panamá
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $144 per night from Dec 6 to Dec 7
CA $144
CA $158 total
Dec 6 - Dec 7
includes taxes & fees
8.6/10 Excellent! (1,730 reviews)
"I am extremely disappointed at the hotel. Specially that for me it was my favourite place to stay in the city. Starting at the reception the desk help was not friendly or helpful at all. I requested a low floor due to my earthquake anxiety and her response was due to the fact that you paid ocean ..."

Reviewed on Nov 5, 2026

Decapolis Hotel Panama City
See all 1,705 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
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Frequently asked questions

How much does a San Francisco vacation package cost?
Much less than you might think — from a low CA $1,853, in fact! By bundling hotels, flights and car rentals into a custom-built vacation package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco vacation package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes traveling on the cheap easy. And with more than 550 partner airlines and 1,000,000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Center. Ph Boutique Quartier Atlapa or New Cozy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travelers.
How far in advance should I book my San Francisco vacation?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco vacation looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia vacation package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco vacation package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco vacation package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.

Stay near popular San Francisco attractions

Multiplaza Pacific Mall

9.0/10 (4,497 reviews)
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
See properties

Things to do

Panama Canal: The Most Complete Monkey Island Experience

Panama Canal: The Most Complete Wildlife Experience

CA $51
per adult
100% of travellers recommend
Panama Canal: The Most Complete Wildlife Experience
Picture 3 for Activity Panama City: All-Inclusive Catamaran Cruise to Taboga Island

Panama City: All-Inclusive Catamaran Cruise to Taboga Island

CA $140
per adult
94% of travellers recommend
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
Half day of Panama city and canal tour: shared and private

Half day of Panama city and canal tour: shared and private

CA $94
per adult
96% of travellers recommend
Half day of Panama city and canal tour: shared and private
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.