San Francisco Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your San Francisco Vacation
When a fun city break is calling, answer it with a vacation package to San Francisco. The neighborhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco vacation is just a few clicks away. Explore flights, accommodations and more on Expedia for an adventure that's tailored to suit your travel style.
Top Holiday Package Deals in San Francisco
Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá
San Francisco
CA $1,163
per person
Nov 24 - Dec 1
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
8.4/10 Very good! (1,693 reviews)
The pool
Is on maintenance, my room had 2 water bottles one was open already I called so they could change it but it never happened. Also the toilet had a stain it look like not watched properly.
Reviewed on Sep 20, 2026
Central Hotel Panama Casco Viejo
Casco Viejo
CA $1,654
per person
Nov 24 - Dec 1
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
9/10 Wonderful! (1,012 reviews)
Such a great experience! I’d recommend it to anyone and love to stay again.
Reviewed on Sep 20, 2026
Where to stay in San Francisco
Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Bella Vista
1 out of top 10 points of interest in this area
Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.
El Cangrejo
The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.
San Felipe
If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.
Calidonia
2 out of top 10 points of interest in this area
You might enjoy the shopping while in Calidonia. Via Espana is a notable sight, and you can get around town at Lotería Station or Santo Tomás Station to see more of the city.
San Francisco Hotel Deals
Megapolis Hotel Panamá
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
CA $194
CA $194 total
Oct 1 - Oct 2
includes taxes & fees
8.6/10 Excellent! (1,742 reviews)
"The pool Is on maintenance, my room had 2 water bottles one was open already I called so they could change it but it never happened. Also the toilet had a stain it look like not watched properly."
Reviewed on Sep 20, 2026
Ramada Plaza by Wyndham Panama Punta Pacifica
Via Israel y Calle 71, San Francisco Panama City Panama
CA $137
CA $151 total
Oct 3 - Oct 4
includes taxes & fees
9.6/10 Exceptional! (1,346 reviews)
"I requested late check out when I checked in. We agreed on a set time. I was called twice during the extended time and housekeeping attempted to enter between those calls. Their communication is poor and the staff were hardly apologetic, except for the housekeeper. Evidently a notation for late check ..."
Reviewed on Sep 21, 2026
Decapolis Hotel Panama City
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
CA $140
CA $154 total
Oct 10 - Oct 11
includes taxes & fees
8.6/10 Excellent! (1,718 reviews)
"El desayuno estaba increíble, el hotel súper limpio, personal atento y perfecta ubicación"
Reviewed on Sep 20, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a San Francisco vacation package cost?
Much less than you might think — from a low CA $1,163, in fact! By bundling hotels, flights and car rentals into a custom-built vacation package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco vacation package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes traveling on the cheap easy. And with more than 550 partner airlines and 1,000,000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Center. Ph Boutique Quartier Atlapa or New Cozy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travelers.
How far in advance should I book my San Francisco vacation?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco vacation looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia vacation package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco vacation package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco vacation package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.
Stay near popular San Francisco attractions
Multiplaza Pacific Mall
9.0/10 (4,497 reviews)
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Via Espana
8.4/10 (2,902 reviews)
During your trip to Panama City, you can find the perfect gifts to bring home at Via Espana. Stroll along the seaside or visit the casinos in this vibrant area.
ATLAPA Conventions Center
7.6/10 (31 reviews)
Learn about the events happening at ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area, or check out its top-notch restaurants.
Multicentro Panama
8.2/10 (274 reviews)
During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.
Pacific Center
You can enjoy retail therapy at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.
Omar Torrijos Recreational Park
5.6/10 (4 reviews)
Omar Torrijos Recreational Park is just one of the places to see in Panama City, so why not enjoy the other things to explore during your travels? Amble around this vibrant area's seaside and enjoy its lively bars.
Things to do
Panama: Monkey and Sloth Jungle Habitat Panama Tour
CA $58
per adult
100% of travellers recommend
Panama Canal: The Most Complete Wildlife Experience
CA $66
per adult
96% of travellers recommend
Half day of Panama city and canal tour: shared and private
CA $92
per adult
98% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.