San Francisco Vacation Packages

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Your San Francisco Vacation

When a fun city break is calling, answer it with a vacation package to San Francisco. The neighborhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco vacation is just a few clicks away. Explore flights, accommodations and more on Expedia for an adventure that's tailored to suit your travel style.

Top Holiday Package Deals in San Francisco

Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was CA $2,067, price is now CA $1,286 per person
CA $1,286
per person
Aug 24 - Aug 29
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very Good! (1,553 reviews)
Rooms clean and spacious

Reviewed on Jun 16, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was CA $3,273, price is now CA $1,695 per person
CA $1,695
per person
Jul 23 - Jul 30
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.2/10 Wonderful! (1,008 reviews)
Spacious and modern room with large bathroom and nice shower. Beautiful music during the day and evening. Excellent breakfast buffet and on-site dining. Pool and pool bar were lovely. Friendly staff. Highly recommend.

Reviewed on Jun 14, 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was CA $2,034, price is now CA $1,325 per person
CA $1,325
per person
Jul 23 - Jul 30
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very Good! (1,832 reviews)
The staff were very friendly. The food was ok at best. The breakfast was very limited and not very appetizing. The only thing near this hotel is the airport.

Reviewed on Jun 16, 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

4 out of 5
Casco Viejo
Price was CA $2,659, price is now CA $1,918 per person
CA $1,918
per person
Aug 23 - Aug 30
found 16 hours ago
Roundtrip flight included
Montreal (YUL) to Panama City (PTY)
9.8/10 Exceptional! (27 reviews)
In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.

Reviewed on Mar 12, 2026

Villa Marina Hotel

Villa Marina Hotel

3.5 out of 5
Price was CA $1,855, price is now CA $1,338 per person
CA $1,338
per person
Aug 23 - Aug 30
found 16 hours ago
Roundtrip flight included
Montreal (YUL) to Panama City (PTY)
9/10 Wonderful! (161 reviews)
The room was spotless clean! The staff was always helpful and ready to serve. Breakfast and food in general was very tasty. The Bar is quite complete

Reviewed on Jun 13, 2026

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
View of the Panama City Old Town

Casco Viejo

4/5(32 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

San Francisco Hotel Deals

Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $186 per night from Jul 4 to Jul 5
CA $186
CA $204 total
Jul 4 - Jul 5
includes taxes & fees
8.6/10 Excellent! (1,001 reviews)
"Not good enough"

Reviewed on Jun 18, 2026

Sheraton Grand Panama
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $200 per night from Jun 20 to Jun 21
CA $200
CA $220 total
Jun 20 - Jun 21
includes taxes & fees
9/10 Wonderful! (1,052 reviews)
"Very confusing having the reception not on the main entrance"

Reviewed on Jun 16, 2026

Las Americas Golden Tower Panama
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $182 per night from Jun 27 to Jun 28
CA $182
CA $200 total
Jun 27 - Jun 28
includes taxes & fees
9/10 Wonderful! (1,001 reviews)
"The room was very clean and the staff friendly and helpful. You can walk right into the Multiplaza mall. We had food in the bar area which was very good."

Reviewed on Jun 15, 2026

Courtyard by Marriott Panama Multiplaza Mall
See all 1,772 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does a San Francisco vacation package cost?
Much less than you might think — from a low CA $1,286, in fact! By bundling hotels, flights and car rentals into a custom-built vacation package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco vacation package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes traveling on the cheap easy. And with more than 550 partner airlines and 1,000,000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Center. Ph Boutique Quartier Atlapa or New Cozy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travelers.
How far in advance should I book my San Francisco vacation?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco vacation looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia vacation package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco vacation package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco vacation package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.

Stay near popular San Francisco attractions

Multiplaza Pacific Mall

9.0/5 (4,497 reviews)
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
See properties
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.